reprocessing of cefotaxime sodium

Do not admix cefotaxime with sodium bicarbonate or any fluid with a pH >7.5. PREPARE:Direct: Add 10 mL diluent to vial with 1 or 2 g drug providing a solution containing 95 or 180 mg/mL, respectively. Intermittent: To 1 or 2 g drug add 50 or 100 mL D5W, NS, D5/NS, D5/.45% NaCl, RL, or other compatible diluent.

The influence of temperature and relative humidity on the stability of cefotaxime sodium in the solid state was investigated. Changes in the concentration of cefotaxime sodium were followed by a HPLC method with UV detection. The kinetic and thermodynamic parameters of the decomposition reaction wer …

Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins …

Pure cefotaxime sodium was kindly supplied by the Egyptian International Pharma-ceutical Industries Co. (EIPICo., Tenth of Ramadan city, Egypt). Hydrochloric acid (HCl) and sodium hydroxide (NaOH) were of analytical grades and were purchased from El-Nasr Chemicals Co. (Cairo, Egypt). Pharmaceutical dosage form, Cefotax® vials …

Cefotaxime injection is also sometimes used to treat typhoid fever (a serious infection that is common in developing countries), salmonella (an infection that causes severe diarrhea) and other types of infectious diarrhea, food poisoning, Lyme disease (an infection that may develop after a person is bitten by a tick), and a certain type of infection from dog bites.

Restricted sodium intake Breastfeeding Pregnancy Renal impairment - glomerular filtration rate below 5 ml/min. ... Cefotaxime constituted with lidocaine must never be used by the intravenous route, in infants under 30 months, in subjects with a previous history of hypersensitivity to this product, in patients who have an unpaced …

Investigation on the Spherical Crystallization Process of Cefotaxime Sodium. Haitao Zhang Ying Chen Jingkang Wang J. Gong. Chemistry, Medicine. 2010. TLDR. A new strategy incorporating the spherical agglomeration technique and the drowning-out crystallization process, by which the impurities can be efficiently removed, was …

View cefotaxime information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, ... For intravenous infusion, manufacturer advises give reconstituted solution intermittently in Glucose 5% or Sodium Chloride 0.9%. Suggested volume 40–100 mL given over 20–60 minutes; incompatible with alkaline solutions. ...

Sterile Cefotaxime for Injection, USP, is a dry off-white to pale yellow crystalline powder supplied in vials and bottles containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid ... Cockcroft, D.W. and Gault, M.H.: Prediction of Creatinine Clearance from Serum Creatinine, Nephron 16:31-41, 1976.

Pure cefotaxime sodium was kindly supplied by the Egyptian International Pharma-ceutical Industries Co. (EIPICo., Tenth of Ramadan city, Egypt). Hydrochloric …

Cefotaxime sodium is highly stable in vitro to four of the five major classes of 5-lactamases described by Richmond et al.1, including type IIIa (TEM) which is produced by many …

Sodium restriction – cefotaxime contains 48.2 mg/g (2.1 mmol/g) sodium. Drug interactions . May potentiate the renal toxicity of nephrotoxic drugs. Should not be combined with bacteriostatic antibiotics (e.g., tetracycline, erythromycin or chloramphenicol) since there may be a potential antagonistic effect.

The selected region showed severe overlap in the UV spectra of cefotaxime sodium and its acidic or alkaline degradation products. Seventeen mixtures were used for the models' construction, and ...

Management: Avoid cefotaxime doses greater than 6 g/day with concurrent probenecid. Any patients receiving this combination should be monitored closely for evidence of cefotaxime toxicity. Consider therapy modification. Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate.

Sodium intake: The sodium content of cefotaxime (2.09mmol/g) should be taken into account when prescribing to patients requiring sodium restriction. Clostridium difficile associated disease (e.g. pseudomembranous colitis): Cefotaxime may predispose patients to pseudomembranous colitis. Although any antibiotic may predispose to …

Indications. Cefotaxime is a beta-lactam antibiotic classified as a third-generation cephalosporin, which was first synthesized in 1976 and is FDA approved to treat gram-positive, gram-negative, and anaerobic bacteria. Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria affecting the lower …

Cefotaxime sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. There is a risk of reversible encephalopathy in cases of administration of high doses of beta-lactam antibiotics including cefotaxime. No specific antidote exists.

Binds to the bacterial cell wall membrane, causing cell death. Therapeutic Effects: Bactericidal action against susceptible bacteria.Spectrum: Similar to that of second-generation cephalosporins, but activity against staphylococci is less, whereas activity against gram-negative pathogens is greater, even for organisms resistant to first- and …

Cefotaxime sodium is most stable at a pH of 5–7 and should not be diluted with IV solutions that have a pH >7.5 (e.g., sodium bicarbonate). Solution Compatibility. Compatible. Dextrose 5 or 10% in water. Dextrose 5% in sodium chloride 0.2, 0.45, or 0.9%. Invert sugar 10%.

Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of Cefotaxime for Injection, USP range from very pale yellow to light amber depending on …

PMID: 36903432. PMCID: PMC10005094. DOI: 10.3390/molecules28052187. Abstract. Four eco-friendly, cost-effective, and fast stability …

CLAFORAN contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of CLAFORAN range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5. The CAS Registry Number is 6.

Cefotaxime for injection is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7- [2- (2-amino-4-thiazolyl ... Following IM administration of a single 500 mg or 1 g dose of Cefotaxime to normal volunteers, mean peak serum concentrations of 11.7 and 20.5 mcg/mL respectively were ...

Cefotaxime sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. There is a risk of reversible encephalopathy in cases of administration of high doses of beta-lactam antibiotics including cefotaxime.

Label: CEFOTAXIME- cefotaxime injection powder, for solution. Label RSS. NDC Code (s): 21586-011-01, 21586-011-02, 21586-012-01, 21586-012-02. Packager: SteriMax Inc. Category: HUMAN PRESCRIPTION DRUG LABEL. DEA Schedule: None. Marketing Status: Unapproved drug for use in drug shortage. DISCLAIMER: This drug has not been …

Sodium restriction – cefotaxime contains 48.2 mg/g (2.1 mmol/g) sodium. Drug interactions . May potentiate the renal toxicity of nephrotoxic drugs. Should not be …

Y:wercs.ps. Revision date: 04-Jan-2010. MATERIAL SAFETY DATA SHEET. Version: 1.0. Page 1 of 6. 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING. Pfizer Inc Pfizer Pharmaceuticals Group 235 East 42nd Street New York, New York 10017 1-212-573-2222 Pfizer Ltd Ramsgate Road Sandwich, Kent.

PMID: 36903432. PMCID: PMC10005094. DOI: 10.3390/molecules28052187. Abstract. Four eco-friendly, cost-effective, and fast stability-indicating UV-VIS spectrophotometric methods were validated for cefotaxime sodium (CFX) determination either in the presence of its acidic or alkaline degradation products.

748 rowsCefotaxime may decrease the excretion rate of Sodium aurothiomalate …

The selected region showed severe overlap in the UV spectra of cefotaxime sodium and its acidic or alkaline degradation products. Seventeen mixtures were used for the models' construction, …

The empirical formula of Cefotaxime (cefotaxime for injection) Sodium is C 16 H 16 N 5 NaO 7 S 2, representing a molecular weight of 477.45. Cefotaxime (cefotaxime for injection) Sodium contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. The diluent chamber contains Dextrose Injection.

Objectives: Describe the pathophysiology of cefotaxime resistance. Identify the most common adverse events associated with cefotaxime therapy. Outline the mechanism of action of cefotaxime. Review some interprofessional team strategies for improving care coordination and communication to advance cefotaxime and improve …

Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium citrate The therapeutic efficacy of Sodium citrate can be decreased when used in combination with Cefotaxime.

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including ...

Objectives: Describe the pathophysiology of cefotaxime resistance. Identify the most common adverse events associated with …

Add 25 mg of sodium carbonate, mix, and allow to stand at room temperature for 10 minutes, with occasional swirling. Add 3 drops of glacial acetic acid and 1 mL of Standard preparation, and mix. Assay preparation— Transfer about 40 mg of Cefotaxime Sodium, accurately weighed, to a 50-mL volumetric flask, add Solution A to dissolve it, dilute ...

CLAFORAN contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of CLAFORAN range from very pale yellow to light amber depending …

Cefotaxime is used to treat a wide variety of bacterial infections. It may also be used to prevent infection from certain surgeries. This medication belongs to a class of drugs known as ...

Cefotaxime Sodium is the sodium salt form of cefotaxime, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Cefotaxime sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of ...

Sterile Cefotaxime for injection, USP is a dry off-white to pale yellow crystalline powder supplied in vials containing cefotaxime sodium as follows: 500 mg cefotaxime (free acid equivalent) in vial. Package of 1 NDC 64679-947-01 Package of 10 NDC 64679-947-02 1 g cefotaxime (free acid equivalent) in vial.