dextran sulfate v

1. Introduction. Dextran sulfate (DXS) is a hydrophilic, biodegradable, biocompatible and negatively charged polysaccharide. It is a highly branched polyanionic polysaccharide with a sulfur content of about 17%, which is approximately equivalent to ~2.3 sulfate groups per glucose unit (Figure 1).This sulfated polysaccharide is produced by …

Dextran sulfate is commonly used in serum-free culture media to reduce cell aggregation in suspension culture. The inhibitory effect of dextran sulfate on the titration of VSV-GFP was confirmed by supplementing the culture medium with this compound during virus production. Our results also demonstrated that extending the incubation time during ...

In skincare, Dextran derivatives, such as Dextran sulfate, can promote better moisture-retention for improved skin hydration. Additionally, Dextran may provide soothing properties that are effective for alleviating dry, problematic skin. 1. Bhavani, A. et al. Dextran—the polysaccharide with versatile uses. Int J Pharm Biol Sci 1, 569-573 (2010)

Dextran sulfate sodium salt is widely used to construct the IBD animal model. It has been assumed in most former researches that DSS induces epithelial damage mainly in the colon and pathological change in the small intestine is ignored (Elsheikh et al., 2012; Kim et al., 2012). In this research, however, it was observed that DSS induced damage ...

Dextran sulfate (DXS) is a hydrophilic, non-toxic, biodegradable, biocompatible and safe biopolymer. These biomedically relevant characteristics make …

Dextran sulfate sodium (3–10%) in the drinking water of rodents results in weight loss and diarrhea after about 10 days (32). Three to five cycles of treatments suffices to start a chronic colitis that does not require further administration. The colitis is characterized acutely by mucosal inflammation and ulcers, worse in the left colon than ...

The low molecular weight dextran sulfate (LMW-DS) used in this study (ILB ®) is a branched polysaccharide with an average molecular weight of 5 kDa and contains molecules spanning approximately 3–8 kDa, in which the α-d-glucopyranose-2,4-sulfate monomers are linked, in 95% of cases, by α-1,6-glycosidic bonds (the main linear chain) …

Thus, the present review first summarizes the physicochemical properties of dextran and its derivatives as well as the modification methods. The fabrication strategies of dextran-based delivery systems that have been applied in the past 5 years are reviewed, and then an in-depth understanding of the molecular interactions among nanomaterials, …

Dextran sulfates are supplied as the sodium salt forms, making them soluble and stable in water. Dextran sulfate contains approximately 17% sulfur which is equivalent to approximately 2.3 sulfate groups per glucosyl residue. Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D- (166) linkages.

Dextran Sulfate (MW > 500,000) is used as an additive in probe hybridization solutions. Its presence accelerates the rate of hybridization by 10 fold. The addition of Dextran Sulfate favors the formation of probe networks, resulting in greater sensitivity during membrane-bound nucleic acid analysis. The product is supplied as a 50% (w/v) solution.

The dextran sulfate sodium (DSS) nanoparticles were formulated with gelation technique. The nanoparticles exhibited significant physicochemical and effective …

Physical characterization of 1% w/v of dextran sulfate sodium (DSS) nanoparticles of batch 3. (A) Zetapotential graph of DSS nanoparticle. (B) Nano size (z d nm) distribution of DSS nanoparticles through particle intensity. (C) Size (r nm) distribution by intensity analysis of DSS nanoparticles. (D) Size (r nm) distribution analysis by mass.

Interventions: Oral dextran sulfate was given three times daily in total daily doses of 900 to 5400 mg for 8 weeks. Patients were monitored for tolerance and toxicity. Immunologic and virologic values were also followed. Measurements and main results: Oral dextran sulfate was given without significant side effects. The commonest minor ...

Descriptions. Iron dextran is an iron replacement product that is used to treat iron deficiency, such as anemia (not enough iron in the blood) or blood loss in patients with certain conditions (eg, hemophilia, gastrointestinal bleeding). Iron is a mineral that the body needs to produce red blood cells. When the body does not get enough iron, it ...

High-voltage LiCoO 2 is an attractive cathode for ultra-high energy lithium-ion batteries in the 5G era. However, the practical application of LiCoO 2 is largely hindered by the unstable structure under high voltage. Herein, dextran sulfate lithium (DSL) is used as a versatile binder to improve the cycling stability of LiCoO 2 at 4.6 V. A coulombic …

Dextran sulfate is a natural, nontoxic, hydrophilic, biodegradable, and negatively charged polysaccharide that can be cross-linked with the positively charged …

In an IBD animal model, the oral administration of polysaccharides such as dextran sulfate sodium (DSS) induced colitis, which exhibited several clinical and histological features similar to IBD. However, pathogenic factors in the development of colitis remain unclear, as do the chemical properties of DSS. Therefore, we investigated the ...

Herein, dextran sulfate lithium (DSL) is used as a versatile binder to improve the cycling stability of LiCoO 2 at 4.6 V. A coulombic efficiency of almost and 93.4% capacity retention after 100 cycles has been achieved.

Dextran sulphate has pharmacological actions similar to that of heparin, but dextran exhibits much prolonged and cumulative anticoagulant effect. A clinical study reported that certain toxic effects have been observed following the treatment with dextran to 15 patients for 3 months at a total dose of 90,000 or more units. The commonest side ...

Low-molecular-weight dextran sulfate (DS) is a sulfated semisynthetic polysaccharide with demonstrated cytoprotective and immunomodulatory properties in vitro. However, whether DS can protect pancreatic β-cells, reduce autoimmunity, and ameliorate T1D is unknown. In this study, we report that DS, but not dextran, protects human β-cells ...

SAFETY DATA SHEET Creation Date 19-Jul-2010 Revision Date 28-Dec-2021 Revision Number 5 1. Identification Product Name Dextran sulfate, sodium salt No. : AC611360000; AC611361000 CAS No Synonyms Dextran Sodium Sulfate Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide …

DS 5,000 Da treatment was shown to prolong the life of cells and increase productivity of EPO by 1.8-fold comparing with controls, in standard batch conditions. At a molecular level, we show that DS inhibits apoptosis by DNA fragmentation delay and decrease of annexin V-labeled cells, causes a G0/G1 cell cycle arrest, decreases p53 expression ...

The most widely used experimental model employs dextran sodium sulfate (DSS) to induce epithelial damage. The DSS colitis model in IBD research has advantages over other various chemically induced experimental models due to its rapidity, simplicity, reproducibility and controllability. In this manuscript, we review the newer publicized …

To investigate the effect of dextran sulfate (DS), a widely used anti-aggregation agent, on cell growth and monoclonal antibody (mAb) production including the quality attributes, DS with the three different MWs (4,000 Da, 15,000 Da, and 40,000 Da) at various concentrations (up to 1 g/L) was added to suspension cultures of two different …

Core tip: In the last few decades the proliferation of research in experimental colitis models of inflammatory bowel diseases (IBD) has had profound effects in our understanding of human IBD pathophysiology as well as to exploit potential therapeutic avenues outside of immunologic therapy. The dextran sodium sulfate colitis model, …

The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ...

Dextran sulfate sodium (DSS)-induced colitis is the most commonly used animal model for inflammatory bowel diseases. However, the precise molecular action of DSS, in particular its initial effect on the epithelial tissue permeability, is still poorly understood. In the present work, organ culture of mouse – and pig colon explants were ...

In North America, multiple formulations of iron are available, but iron salts such as ferrous gluconate, ferrous sulfate, and ferrous …

Dextran Sulphate Sodium (DSS) Certain types of dextran functionalization can lead to very toxic compounds, which can, however, be useful for particular applications. DSS is a polyanionic derivative of dextran with high-water solubility properties containing approximately 17% sulphur with up to three sulphate groups ...

Many drugs targeting the immune responses of IBD have been developed, but their application has many problems, including side effects and high costs. Therefore, there is an urgent need for new drugs. In this study, we investigated the preventive effects of DSF+Cu 2+ on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice.

Both proteins bind polyphosphate, heparin, and dextran sulfate with high affinity. Through this mechanism they inhibit the autoactivation of factor XII and factor XI, the reciprocal activation of factor XII and prekallikrein, the activation of factor XI by thrombin and factor XIIa, the cleavage of high-molecular-weight kininogen in plasma, and ...

A homogenous α-D-1,6-glucan (CPA) was extracted from Castanea mollissima Blume. The effect of CPA on ameliorating dextran sulfate sodium induced colitis was investigated. CPA repressed TNF-α and IL-1β level in LPS stimulated RAW264.7 cells. After the intragastric administration of CPA (200 or 400 mg …

Dextran is a medication used to treat hypovolemia (decreased volume of circulatory plasma blood) resulting from surgery, trauma, severe burns, or other causes of bleeding. Common side effects of dextran include mild itching, rash, body aches, numbness or tingly feeling, nausea, vomiting, stomach pain, diarrhea, mild dizziness, weakness, low …

In this study, we investigated the preventive effects of DSF+Cu 2+ on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. Methods: The anti-inflammatory effects were investigated using the DSS-induced colitis mouse model and lipopolysaccharide (LPS)-induced macrophages. DSS-induced TCRβ -/- mice were used …